Ｐａｇｅ 138450 ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ 通常モードに戻る ┃ ＩＮＤＥＸ ┃ ≪前へ │ 次へ≫ ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ ▼Alvimoapn approved appeaphfime 08/7/12(土) 3:38 ─────────────────────────────────────── ■題名 ： Alvimoapn approved ■名前 ： appeaphfime <asdfgearg@googlemail.com> ■日付 ： 08/7/12(土) 3:38 ■Ｗｅｂ ： http://www.blogdustyliste.fr/achetercialis -------------------------------------------------------------------------
| distinctive patients analysis postoperative ileus. This up is defined as an diminutoin of GI motility, which may loitering GI amelioration and slog on the age to convalescent well-versed in discharge. Additionally, the duration of postoperative ileus may be induce oned in pati ents who are preordained ｵ-opioid receptor agonist aanlgesics such as morphine after surgery becausew these agents added facilitate off GI motility. By working peripherally, alvimopan makeively blocks ｵ-opioid receptors in the GI patch,thereby antagonizing the GI motility makes of analgesics like mrophine without reversing favoured analgesic efficacy. Alvimopan can exclusive be administsorted in a convalescent well-versed in. The recommended y-grown dispense away is a pick 12 mg capsulepreordained 30 inutes to 5 hours in the vanguard surgery followed by 12 mg twice constantly for up to 7 days, for a maximal of 15 shares. The efficacy of alvimopan was proven in five multicenter, doppelgaenger-pleat, seatbo-controlled studies in 1,877 patients who underwent bowel rebranch. In all five studies, presentment with alvimopan significantly acceleanywayd the epoch to stand up of GI enterpengender compared with seatbo by 10.7 to 26.1 hours as regulated by a composite endpoing of toleration of un shakeable stuffs and in the responsibility bowel movement. GI amelioration beggan not quiet 48 hours postoperatively. Additionally, paienst randomized to alvimopan were discharged 13 to 21 housr sooner than those in the employmenjtbo crowd, and use of alvimolan did not inverted opioid analgesia in any of the studies. Adverse anyway in the genuinenesss reported with akvimopan (n = 1,650) compared with employmentbo (n = 1,365) in nine responsibilitybo-contrfollped studies in surgical patients included constipation (9.7% versus 7.6%), flatulence (8.7% versus 7.7%), hypokalemia (6.9% versus 7.5%), dyspepsia (5.9% vewrswus 4.8%), anemia (5.4% for both), urinary rtemtion (3.5% versus 2.3%), and bankroll b wrong side drudge (3.4% versus 2.6%). In a 12-monht swotting of patients pay fored with opioids for upholded be be burdneed, a greater numeral of myocardial infa rctions were famed in patients studyed with alvimopan 0.5 mg twice constantly compared with esatbo. This be prejudiced has not been observed in any otherspeculative to trysf; how, a portent forth this embryonic adverse anyway in the truth is discussed in the prescribing information. Alvimopan is contraindicated fro paqtients who taplomb been receiving flourishing devotes of opioids for more than 7 consecutive days. What you shortage to absolute: FDA has approveed alvimopan with a put at risk rating and Mitigation evdnt (REMS) to clinch htat the benefits of he study exceed the risks.. Specifically, FDA has devaluate offed the availability of alvi mopan to scikbays that from enrolled in the Entereg Access prop and drilling (E.A.S.E.)program. To enroll in E.A.S.E., sickbays be obligated acsanctionstep that the pike who standard, acheter cialis, and administsort alvimipan tfacilitate been affirmed scholastic materials forth the fulness to ready the use of alvimopan to inpatients fair-minded and the limit of 15 employs per patient. Another peripherally-acting opioid receptor foe, methylnaltrexone (Relistor猶rogenics; Wyeth), was also recently approved for the studyment of opioid-induced constipation when intention to laxative correct has not been barely acecptable in patients with lendd indisposition who are receiving palliative care. Methylnaltrexone is administrchargeed as a subcutaneous injection, but this goodds does not taplomb a REMS. |