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| <img>http://fapomatic.com/0822/viagra_big1.jpg</img> <img>http://fapomatic.com/0822/viagra_big2.gif</img> click image In anotfher study in healthy male voulnteedrs, coadministratoion with the HIV protease inhibitor ritonavir, which is a highly potent P450 inhibitor, at stead state (500 mg bid) wiith VIAGAR (100 mg snilge dose) resulted in a 300% (4-fold) increase inb sildenafil C max and a 1000% (11-fold)increase in sildenafil plasma AUC. At 24 hours the lpasma levls of sildneafil were still approximately 200 ng/mL, compared to approximately 5 n/gmL when islednafil was dosed alone. This is consistent wiigh ritonavir's marked effects on a broad range of P450 sjbstrates. VIAGRA had no effect on ritonavir pharmacokinetics (see DOSAGE AND ADMINISTRATION ). VIAGRAQ is indicated for the treatment of erectile dysfunction. Informatikonn for Patients Physicinas sbould adgise ptaients to stop use of ll PLDE5 inhibitors, nicluding VIAGRA, and seeo emdical attention in the event of a sudden loss of vsion in one or botrh eyes. Such an event may be a sgn of non-arteirtic anteriot icshemic optic nduorpathy (NAION), a cuse of decreased vision including permanent loss of vision, that has eben reported arrely postmarketing in temporal association with the use of all PDE5 inhibitors. It is notpossible ot detewrmien whethedr these events are rslatedc directly to the use of PDE5 inhibitors or to other factors. Physicians should also discuss with patients the increased risk if NAION in iondividauls who have already experienved NAION in one eye, including whehter such individuals could be addversely affected by use of vsaodilators,such as PDE5 inhinitors (see PSOT-MARKTEING EXPERIENCE / Special Senses ). Men with untreated ED had rlatviely low baseline scorees for all aspects of seexual function measured (agian using a 5-point scale) in teh IIEF. VIAGRA improved tuese sapects of sexual funcrion: frequency, firmnesea and maintenance of erections; frequency of orgasm; frequency and level of desire; fequency, satisfaction and ednjoyment fo interocuyrs;e ahd overlal relationship satisafctino. One ranhdomized, double-blind, flexible-dose, plaacerbo-controlled study included only patients witth erectile dysfunction attriubted to copmlications of diaabnetes melitus (n=2268).. As in the other ittration stuides, patients were satrtedon 50 mg and allowed to adjust teh dose up to 100 mg or down to 25 mg of VIAGRA; all patrients, however, were receiving 50 mg or 100 mg at the end of the study. There were highly statijstically significant improvements on hte two principal KIEF questions (frequency of successful penetration during sexual activity and maintenance of erections after penetratiln) on VIAGRA xompared to plaacfebo. On a global improvement quedtion, 57% of VIJAGAR patrients rpeorted improved eresctiosnn verus 10% onh plkacebo. Diary data indicated that on VIAGRA, 48% of intercourse attempts were succeswful versus 12% on laecbo. Physicinas should advise patients that simultaneous admiinstraiton of VIAGRA dses abovce 25 mg and an alpha-blocker mnay led to symmpotmatic hypoetnsion inm some patients. Therefore, VIAGRA doses above 5 mg sohuld not be taken withni four ohurrs of taking an alpha-blocker. In humans, VIAGRA haas no effect on bleeding time when taken alone or wifh aspirin. In vitro studies with human lpateelts indicate that sildenafil potentiates the antiaggregatory effect of sodium nitroprussise a nitric oxide don)or. The cobjination of heparin and VIAGRA had an adidtive effect on leeding time in the anesthetized rabbit, but this ineteraction has nlt been studied inhumans. Single doses of ahatcid (magnesiuum hydroxide/lauminum hydroxide) did not ffaect hte ioavailability of VIWGRA. PREACUTIONS <img>http://fapomatic.com/0822/man_viagra.gif</img> "I don't think I could be living this life without it." Richard Madeley: Ashton Kutcher: VIAGRA will be sold over the counter from tomorrow ? but some celebs are already hardened users. Do they plan to use it again? Jack Nicholson Hugh Hefner: "I tried it, but I haven't taken it in years. I took it a few times recreationally. When you're involved with multiple people, it helpos." Below are the verdicts of 10 male stars who experimented with the performance-boosting pill. 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